Novikov A M, Merabishvili N V, Bassalyk L S
Vopr Onkol. 1982;28(3):67-73.
The report deals with the studies of lipid profile of blood serum and alpha-lipoproteins in 59 cases of epithelial ovarian tumors as well as the effects of surgery and chemotherapy on the serum levels of major lipids. Triglyceride and phospholipid levels In the serum of cancer patients appeared to be much higher than in healthy controls. Serum lipid distribution patterns were normal in patients with benign tumors of ovaries. Serum levels of total cholesterol and alpha-lipoprotein phospholipids in cancer patients were much lower than in healthy controls thus pointing to a considerably decreased level of this fraction of lipoproteins. Surgery was shown to be followed by a noticeable rise in triglyceride levels and a decrease in serum phospholipid concentration in cancer patients. Post-operative polychemotherapy was followed by reversed changes in triglyceride and phospholipid concentrations. It was found that polychemotherapy is not an important factor affecting the serum level of alpha-lipoproteins in untreated patients.
该报告涉及对59例上皮性卵巢肿瘤患者血清脂质谱和α-脂蛋白的研究，以及手术和化疗对主要脂质血清水平的影响。癌症患者血清中的甘油三酯和磷脂水平似乎远高于健康对照组。卵巢良性肿瘤患者的血清脂质分布模式正常。癌症患者的血清总胆固醇和α-脂蛋白磷脂水平远低于健康对照组，这表明该部分脂蛋白水平显著降低。结果显示，癌症患者手术后甘油三酯水平显著升高，血清磷脂浓度降低。术后多药化疗后，甘油三酯和磷脂浓度发生相反变化。研究发现，多药化疗不是影响未治疗患者血清α-脂蛋白水平的重要因素。
