慢反应物质（SRS）对豚鼠气管平滑肌中环核苷酸的影响。

Effects of SRS (slow reacting substance) on cyclic nucleotides in guinea pig tracheal muscle.

作者信息

Hedman S E, Andersson R G

出版信息

Acta Pharmacol Toxicol (Copenh). 1982 Jan;50(1):30-4. doi: 10.1111/j.1600-0773.1982.tb00936.x.

DOI:10.1111/j.1600-0773.1982.tb00936.x

Abstract

Leukotriene (SRS) appears to contribute to the prolonged phase of the tracheal contraction induced by egg albumin, indomethacin and tartrazine as this response was effectively antagonised by FPL 55712. Egg albumin, indomethacin and tartrazine reduced the cAMP level of guinea pig trachea pretreated with adrenergic, cholinergic, histaminergic and 5-hydroxytryptaminergic antagonists. Egg albumin, but not the other agents, caused a transient increase of the cGMP content. The metabolic and contractile effects were blocked by FPL 55712. It is suggested that the cAMP reduction caused by egg albumin, indomethacin and tartrazine might promote contractions ot the tracheal muscle.

摘要

白三烯（慢反应物质）似乎与卵清蛋白、吲哚美辛和酒石黄诱导的气管收缩的延长阶段有关，因为FPL 55712可有效拮抗这种反应。卵清蛋白、吲哚美辛和酒石黄降低了用肾上腺素能、胆碱能、组胺能和5-羟色胺能拮抗剂预处理的豚鼠气管的环磷酸腺苷（cAMP）水平。卵清蛋白而非其他药物导致环磷酸鸟苷（cGMP）含量短暂升高。FPL 55712可阻断代谢和收缩效应。提示卵清蛋白、吲哚美辛和酒石黄引起的cAMP降低可能促进气管肌肉收缩。