Yoshimoto J, Matsumura Y, Tanahashi T, Ohmori H, Tokiwa T, Sato J
Acta Med Okayama. 1982 Feb;36(1):61-6. doi: 10.18926/AMO/30702.
The effects of steroid sex hormones on the established cell lines derived from human urinary bladder cancer, T24, and from human transitional cell cancer of the urinary tract, 253J, were examined using the colony formation method. Of the seven kinds of steroid hormones tested, estradiol-17 beta was intensively cytotoxic for both cells. The cytotoxic effect was depended on the dose and time of treatment. The combined effect of Adriamycin and estradiol-17 beta on T24 cells could be recognized at low concentrations of Adriamycin (less than or equal to 10(-3) micrograms/ml) after exposure for 24 h.
使用集落形成法研究了甾体性激素对源自人膀胱癌T24细胞系以及源自人泌尿道移行细胞癌253J细胞系的影响。在所测试的七种甾体激素中，雌二醇-17β对这两种细胞均具有强烈的细胞毒性。细胞毒性作用取决于处理的剂量和时间。阿霉素和雌二醇-17β对T24细胞的联合作用在暴露24小时后，在低浓度阿霉素（小于或等于10^(-3)微克/毫升）时即可显现。
