Breddin K
Z Gesamte Inn Med. 1978 Sep 1;33(17):615-21.
An arterial thrombosis develops via a lesion of the vascular wall. By the contact of the flowing blood with subendothelial collagen and basal membrane proportions the adhesion and aggregation of platelets develop which, depending on flowing conditions and local conditions, such as ADP-concentration, may lead to manifest thromboses. The prostaglandines have an essential influence on these processes. The relations of thrombosis to arteriosclerosis consist in the stimulation of the smooth muscle cells to proliferation by a factor of thrombocytes, in the organisation of experimental arterial thromboses with formation of an intima proliferation and in the complications of manifest arteriosclerosis by secondary thromboses. Methods for the proff of an increased inclination to thrombosis on the basis of an increased platelet function are critically discussed as to their clinical usability. A spontaneously increased aggregation of platelets is regarded as a reference to progressing arteriosclerosis. In these cases the significant increase of the spontaneous aggregation is of special importance in diabetics.
动脉血栓形成是通过血管壁损伤发展而来的。流动的血液与内皮下胶原蛋白和基底膜成分接触后，血小板发生黏附与聚集，这取决于血流状况和局部条件，如ADP浓度，可能导致明显的血栓形成。前列腺素对这些过程有重要影响。血栓形成与动脉硬化的关系在于，血小板因子刺激平滑肌细胞增殖，实验性动脉血栓形成并伴有内膜增殖，以及明显动脉硬化因继发性血栓形成而出现并发症。关于基于血小板功能增强来证明血栓形成倾向增加的方法，就其临床实用性进行了批判性讨论。血小板自发聚集增加被视为动脉硬化进展的参考指标。在这些情况下，糖尿病患者中自发聚集的显著增加尤为重要。
