糖皮质激素对人绒毛膜促性腺激素分泌的刺激作用。

Stimulation of human chorionic gonadotropin secretion by glucocorticoids.

作者信息

Wilson E A, Jawad M J

出版信息

Am J Obstet Gynecol. 1982 Feb 1;142(3):344-9. doi: 10.1016/0002-9378(82)90741-4.

Abstract

The effects of glucocorticoids on hormone secretion by human placenta in organ culture were studied. The addition of cortisol resulted in a fourfold increase in human chorionic gonadotropin (hCG) secretion over that in untreated cultures after 144 hours' incubation (P less than 0.05), and a twofold increase in hCG was observed in the presence of cortisone (P less than 0.01). Dexamethasone stimulated hCG secretion in a dose-response manner (r = 0.9542; P less than 0.01). Progesterone, which suppresses hCG under these conditions, decreased the cortisol-enhanced secretion of hCG (r = -0.9794; P less than 0.01). No change in the secretion of human chorionic somatomammotropin was observed, but glucocorticoids increased heat-stable alkaline phosphatase activity (P less than 0.001). The physiologic significance of glucocorticoid effects on placental hormone synthesis is discussed.

摘要

研究了糖皮质激素对器官培养的人胎盘激素分泌的影响。孵育144小时后，添加皮质醇导致人绒毛膜促性腺激素（hCG）分泌量比未处理的培养物增加了四倍（P<0.05），在存在可的松的情况下观察到hCG增加了两倍（P<0.01）。地塞米松以剂量反应方式刺激hCG分泌（r = 0.9542；P<0.01）。在这些条件下抑制hCG的孕酮降低了皮质醇增强的hCG分泌（r = -0.9794；P<0.01）。未观察到人类绒毛膜生长催乳素分泌的变化，但糖皮质激素增加了热稳定碱性磷酸酶活性（P<0.001）。讨论了糖皮质激素对胎盘激素合成影响的生理意义。