Oster P, Arab L, Kohlmeier M, Mordasini R, Schellenberg B, Schlierf G
Am J Obstet Gynecol. 1982 Mar 15;142(6 Pt 2):773-5. doi: 10.1016/s0002-9378(16)32487-5.
Because the incidence of venous thromboembolism, coronary heart disease, and stroke is increased in users of oral contraceptives (OCs), the possible causal metabolic side effects of OCs have been widely investigated. In this article we present epidemiologic data associated with OC use. Total plasma triglycerides and cholesterol levels were elevated in OC users while high-density lipoprotein cholesterol levels were lowered. Another section discusses some hormone-dependent physiologic and pathophysiologic aspects of lipid metabolism. Finally, we report on the isolated influence of estrogens and progestogens and their interrelation, including some recent findings about the effects of different progestogens on lipoproteins.
由于口服避孕药（OCs）使用者发生静脉血栓栓塞、冠心病和中风的几率增加，人们对OCs可能产生的因果代谢副作用进行了广泛研究。在本文中，我们展示了与使用OCs相关的流行病学数据。口服避孕药使用者的血浆总甘油三酯和胆固醇水平升高，而高密度脂蛋白胆固醇水平降低。另一部分讨论了脂质代谢的一些激素依赖性生理和病理生理方面。最后，我们报告了雌激素和孕激素的单独影响及其相互关系，包括一些关于不同孕激素对脂蛋白影响的最新发现。
