Sturgess J, Imrie J
Am J Pathol. 1982 Mar;106(3):303-11.
The development of the tracheal submucosal glands has been determined quantitatively in 22 infants with cystic fibrosis and in 25 control infants, all under 4 months of age. In cross-sections of normal trachea significant relationships were found between postconceptional age (PCA) and gland area (P less than 0.001), submucosal area (P less than 0.02), tracheal airway diameter (P less than 0.05), and acinar diameter (P less than 0.001). In infants with cystic fibrosis the pattern of development was similar to that of the control infants. No statistically significant differences were found between three subgroups of infants with cystic fibrosis, which included those with meconium ileus with no lung infection, those with meconium ileus with lung infection, and those with lung infection and no history of meconium ileus. The normal pattern of development of tracheal submucosal glands in infants with cystic fibrosis was in contrast to the deficiency of normal maturation seen in the exocrine pancreas of these infants. The lumen fraction, an index of dilatation of acinar lumina, showed no significant relationship with PCA in either the control group or the group with cystic fibrosis. However, statistically significant dilatation of acini was observed in the tracheal submucosal glands of infants with cystic fibrosis (0.14, P less than 0.005).
对22名患有囊性纤维化的婴儿和25名对照婴儿（均小于4个月龄）的气管黏膜下腺发育情况进行了定量测定。在正常气管的横切面上，发现受孕后年龄（PCA）与腺体面积（P<0.001）、黏膜下面积（P<0.02）、气管气道直径（P<0.05）和腺泡直径（P<0.001）之间存在显著关系。患有囊性纤维化的婴儿的发育模式与对照婴儿相似。在患有囊性纤维化的婴儿的三个亚组之间未发现统计学上的显著差异，这三个亚组包括胎粪性肠梗阻且无肺部感染的婴儿、胎粪性肠梗阻且有肺部感染的婴儿以及有肺部感染且无胎粪性肠梗阻病史的婴儿。囊性纤维化婴儿气管黏膜下腺的正常发育模式与这些婴儿外分泌胰腺中正常成熟的缺乏形成对比。腺腔分数是腺泡腔扩张的指标，在对照组或囊性纤维化组中，其与PCA均无显著关系。然而，在患有囊性纤维化的婴儿的气管黏膜下腺中观察到腺泡有统计学上的显著扩张（0.14，P<0.005）。
