Lemon G J, Bassingthwaighte J B, Kelly P J
Am J Physiol. 1982 Mar;242(3):E146-53. doi: 10.1152/ajpendo.1982.242.3.E146.
The exchange of calcium and strontium ions in bone was studied in control dogs, dogs made hypocalcemic by parathyroidectomy, and dogs rendered hypercalcemic by injection of parathyroid hormone. After injections of tracer into the tibial nutrient artery, extraction of tracer during transcapillary passage was measured and expressed as a fraction of 1. Extraction over the first 3 min in normal dogs was 0.46 +/- 0.09 (n = 6), in hypocalcemic dogs it was increased to 0.53 +/- 0.07 (n = 6), and in hypercalcemic dogs it was decreased to 0.39 +/- 0.07 (n = 5). Subsequent washout was less rapid than normal in hypoparathyroid dogs and more rapid than normal in hyperparathyroid dogs. We conclude from this that the immediate volume of distribution in bone (or the number of available binding sites) for strontium diminishes as the parathyroid hormone level increases.
对正常犬、甲状旁腺切除致血钙过低的犬以及注射甲状旁腺激素致血钙过高的犬的骨骼中钙和锶离子交换情况进行了研究。向胫骨滋养动脉注射示踪剂后，测量示踪剂在毛细血管通过过程中的摄取量，并表示为1的分数形式。正常犬在最初3分钟内的摄取率为0.46±0.09（n = 6），血钙过低的犬增加到0.53±0.07（n = 6），而血钙过高的犬则降低到0.39±0.07（n = 5）。甲状旁腺功能减退的犬随后的洗脱速度比正常犬慢，而甲状旁腺功能亢进的犬则比正常犬快。由此我们得出结论，随着甲状旁腺激素水平升高，骨骼中锶的即时分布容积（或可用结合位点数量）会减少。
