Granger D N, Perry M A, Kvietys P R, Taylor A E
Am J Physiol. 1982 Mar;242(3):G194-201. doi: 10.1152/ajpgi.1982.242.3.G194.
The purpose of this study was to determine whether the postprandial increase of intestinal lymphatic protein flux is due to an increased capillary permeability. Intestinal lymph flow and lymph (L) and plasma (P) protein concentrations were measured at various venous pressures under control conditions, after cream feeding, and during intraluminal perfusion with a bile-oleic acid solution. The osmotic reflection coefficient (sigma d), a measure of capillary permeability that is independent of surface area, was estimated under all conditions, assuming sigma d = 1 - L/P at high capillary filtration rates. The results acquired indicate that cream feeding and intraluminal perfusion with bile-oleic acid significantly increases intestinal capillary permeability. Pretreatment with indomethacin and antihistamines did not alter the permeability increase induced by intraluminal bile-oleic acid. Intra-arterial infusion of cholecystokinin and secretin did not increase intestinal capillary permeability. These studies indicate that the postprandial increase in intestinal lymphatic protein flux is due at least in part, to an increase in capillary permeability. Cholecystokinin, secretin, histamine, and prostaglandins do not appear to mediate the increased intestinal capillary permeability during fat absorption.
本研究的目的是确定餐后肠道淋巴蛋白通量的增加是否归因于毛细血管通透性的增加。在对照条件下、进食奶油后以及腔内灌注胆汁 - 油酸溶液期间，于不同静脉压力下测量肠道淋巴流量以及淋巴（L）和血浆（P）蛋白浓度。在所有条件下，假设在高毛细血管滤过率时σd = 1 - L/P，估算渗透反射系数（σd），这是一种独立于表面积的毛细血管通透性测量指标。获得的结果表明，进食奶油和腔内灌注胆汁 - 油酸会显著增加肠道毛细血管通透性。用吲哚美辛和抗组胺药预处理并未改变腔内胆汁 - 油酸诱导的通透性增加。动脉内输注胆囊收缩素和促胰液素并未增加肠道毛细血管通透性。这些研究表明，餐后肠道淋巴蛋白通量的增加至少部分归因于毛细血管通透性的增加。胆囊收缩素、促胰液素、组胺和前列腺素似乎并未介导脂肪吸收期间肠道毛细血管通透性的增加。
