Fitzcharles M A, Halsey J, Currey H L
Ann Rheum Dis. 1982 Feb;41(1):66-8. doi: 10.1136/ard.41.1.66.
An attempt was made to convert 24 patients on corticosteroid treatment from a daily to an alternate daily regimen. Ten patients were successfully converted, 11 failed to convert, and 3 had to be withdrawn for irrelevant reasons. A simple tetracosactrin stimulation test gave some indication of which patients were more likely to convert successfully. Success was not influenced by severity or duration of disease, nor by dose of duration of steroid therapy. Conversion did not influence various clinical and laboratory measures of undesirable steroid side effects, but the follow-up period was probably too short to judge this. The evidence of others suggests that conversion is worth attempting.
尝试将24名接受皮质类固醇治疗的患者从每日给药方案转换为隔日给药方案。10名患者成功转换，11名转换失败，3名因无关原因不得不退出。一项简单的二十四肽促皮质素刺激试验对哪些患者更有可能成功转换给出了一些指示。成功与否不受疾病严重程度或持续时间的影响，也不受类固醇治疗的剂量或持续时间的影响。转换对类固醇不良副作用的各种临床和实验室指标没有影响，但随访期可能太短，无法据此作出判断。其他研究证据表明，转换是值得尝试的。
