Kirsner A B, Farber S J, Sheon R P, Finkel R I
Ann Rheum Dis. 1982;41 Suppl 1(Suppl 1):32-3. doi: 10.1136/ard.41.suppl_1.32.
One hundred and twenty-six patients with definite or classical rheumatoid arthritis admitted to hospital between 1965 and 1974 for cytotoxic therapy were studied for the presence and type of malignant disease. Each of the cytotoxic treated patients was age and sex matched to a rheumatoid arthritis patient admitted to hospital during the same years but who did not receive cytotoxic therapy. There was no increase in malignancy in the cytotoxic treated group over the control group.
对1965年至1974年间因细胞毒性疗法入院的126例确诊或典型类风湿性关节炎患者进行了恶性疾病的存在情况及类型研究。接受细胞毒性治疗的每位患者在年龄和性别上都与同年入院但未接受细胞毒性治疗的类风湿性关节炎患者相匹配。与对照组相比,细胞毒性治疗组的恶性肿瘤发生率并未增加。