在重度高血压治疗中，将哌唑嗪添加到标准三联疗法中。
The addition of prazosin to standard triple therapy in the treatment of severe hypertension.
作者信息
Heagerty A M, Russell G I, Bing R F, Thurston H, Swales J D
出版信息
Br J Clin Pharmacol. 1982 Apr;13(4):539-41. doi: 10.1111/j.1365-2125.1982.tb01418.x.
Abstract
1 A small dose of prazosin was added to the treatment regime of sixteen hypertensive patients poorly controlled on a combination of bendrofluazide, hydralazine and propranolol. 2 There was a significant improvement in blood pressure control in all patients at 1 month (P less than 0.01) and this was maintained at 9 months (P less than 0.02). Tolerance to prazosin was not a problem. 3 The addition of prazosin to conventional triple drug therapy produces a further useful fall in blood pressure.
摘要
- 对16名使用苄氟噻嗪、肼屈嗪和普萘洛尔联合治疗但血压控制不佳的高血压患者，在其治疗方案中添加小剂量哌唑嗪。2. 所有患者在1个月时血压控制有显著改善（P<0.01），并在9个月时维持这一效果（P<0.02）。对哌唑嗪的耐受性不是问题。3. 在传统三联药物治疗中添加哌唑嗪可使血压进一步有效下降。
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