Roudier M, Portha B, Picon L
Biol Neonate. 1982;41(3-4):143-7. doi: 10.1159/000241543.
In the fetal rat, plasma corticosterone concentration (PCC) decreases dramatically on the 20th day of gestation and remains low until birth even if the parturition is delayed until 23.5 days postcoitus. In the normal term newborn, there is an increase of PCC in the 1st h after birth. In postmature newborn rats this increase is not present but PCC can be increased towards normal term values if the adrenal cortex is stimulated with cosyntropin or lysine-vasopressin. This suggests that the lack of elevation of PCC in the postmature newborn is not due to the lack of responsiveness of the adrenal cortex but rather an impairment of the hypophyseal stimulation. The absence of PCC elevation at birth could contribute to the metabolic disorders observed in the postmature newborn rat.
在胎鼠中，妊娠第20天时血浆皮质酮浓度（PCC）急剧下降，并且一直保持在低水平直至出生，即使分娩延迟到交配后23.5天。在足月正常新生儿中，出生后第1小时PCC会升高。在过熟新生儿大鼠中，这种升高不存在，但如果用促肾上腺皮质激素或赖氨酸加压素刺激肾上腺皮质，PCC可升高至足月时的值。这表明过熟新生儿中PCC缺乏升高并非由于肾上腺皮质反应性缺乏，而是垂体刺激受损。出生时PCC缺乏升高可能导致过熟新生儿大鼠中观察到的代谢紊乱。
