Quantitative determination of trimetoquinol in plasma as its mixed pentafluoropropionyl-trimethylsilyl derivative by gas chromatography mass spectrometry.
作者信息
Suzuki T, Tsuzurahara K, Murata T, Takeyama S
出版信息
Biomed Mass Spectrom. 1982 Mar;9(3):94-8. doi: 10.1002/bms.1200090303.
PMID:7066482
Abstract
A method is described for the determination of the bronchodilator trimetoquinol in plasma, based on selected ion monitoring gas chromatography mass spectrometry employing a deuterated trimetoquinol as internal standard. N-methyl-(trimethylsilyl)pentafluoropropionamide and N-methyl-bis-pentafluoropropionamide were prepared for derivatization of trimetoquinol into a mixed O-TMS-N-PFP derivative, which was found to be the most suitable form in terms of sensitivity, specificity and efficiency. The calibration curve was linear in the range of 2-50 ng ml-1, and the lower limit of detection was 0.1 ng ml-1 of rat plasma.
摘要
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