Lipolytic and adenyl-cyclase-stimulating activity of N alpha-trinitrophenyl glucagon: comparison with other glucagon derivatives modified at the amino terminus.

The trinitrophenyl (TNP) derivative of glucagon has less lipolytic activity and potency than the carbamyl derivative. The N alpha, e-acetyl derivative has slightly less activity than the TNP derivative. In contrast to liver, where the TNP derivative fails to stimulate adenyl cyclase, all the derivatives stimulate this enzyme in the adipocyte.