Fisher R S, Levine M S, Hull C D, Buchwald N A
Brain Res. 1982 Mar;255(3):443-62. doi: 10.1016/0165-3806(82)90010-4.
Single unit extracellular responses evoked by striatal, cortical, and somatosensory stimulation were recorded in substantia nigra (SN) neurons of kittens (1-70 days of postnatal age) and adult cats. Neuronal responses to stimulation of each site were obtained throughout postnatal development. However, 4 major developmental shifts in the response of neurons were found: (1) the responsiveness of neurons to orthodromic activation increased with age; (2) the signs of the initial responses of neurons to orthodromic activation increased with age; (2) the signs of the initial responses of neurons to caudate and cortical stimulation changed with age (excitatory and inhibitory responses in kittens vs almost entirely inhibitory responses in adults); (3) the the response latencies of neurons decreased with age; (4) nigral neurons that were activated antidromically by stimulation of nigrostriatal axons showed age-related decreases in refractory periods and increases in conduction velocities.
