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大鼠发育中视网膜神经节细胞的丧失。

The loss of ganglion cells in the developing retina of the rat.

作者信息

Potts R A, Dreher B, Bennett M R

出版信息

Brain Res. 1982 Mar;255(3):481-6. doi: 10.1016/0165-3806(82)90013-x.

DOI:10.1016/0165-3806(82)90013-x
PMID:7066701
Abstract

Horseradish peroxidase (HRP) was injected into both sides of the brain of newborn and adult rats. The number of retinal ganglion cells was estimated by counting cells containing granules of HRP reaction product. The mean number of labelled cells in 2-day-old animals was 169,500 (S.D. +/- 16,000, n = 6). By the tenth postnatal day the mean number of labelled cells had fallen to 113,500 (+/- 2900, n = 3). This value is similar to the mean number of labelled cells in the adult animal (113,000 +/- 2700; n = 4). Thus, during the first few postnatal days the number of retinal cells projecting to the central visual nuclei is reduced by at least 35%.

摘要

将辣根过氧化物酶(HRP)注射到新生大鼠和成年大鼠的双侧脑内。通过计数含有HRP反应产物颗粒的细胞来估计视网膜神经节细胞的数量。2日龄动物中标记细胞的平均数量为169,500个(标准差±16,000,n = 6)。到出生后第10天,标记细胞的平均数量降至113,500个(±2900,n = 3)。该值与成年动物中标记细胞的平均数量相似(113,000±2700;n = 4)。因此,在出生后的头几天内,投射到中枢视觉核的视网膜细胞数量至少减少了35%。

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