Mainwood G W, Rakusan K
Can J Physiol Pharmacol. 1982 Jan;60(1):98-102. doi: 10.1139/y82-016.
A model for oxygen transfer to cells from capillaries is considered in which mitochondria are either clustered at the cell periphery around capillaries or homogeneously distributed through the cytosol. The capillary Po2 required to supply cells utilizing oxygen at the same rate is much less when mitochondria cluster around capillaries. Two alternative mechanisms are considered for distributing energy from peripheral mitochondria to the rest of the cell; i.e., diffusion of ATP or creatine phosphate with enough creatine kinase to ensure equilibrium between the approximately P carriers. The latter has clear advantages and would appear to be adequate to supply a fairly large mitochondria-free cell core (e.g., 24-micrometer diameter) with very little change in ADP levels or in the free energy of ATP hydrolysis at maximum work rates. Thus, a viable alternative to the traditional Krogh model is presented which takes into account the inhomogeneity of the diffusion pathway as a result of mitochondrial clustering.
考虑一种从毛细血管向细胞进行氧传递的模型，其中线粒体要么聚集在毛细血管周围的细胞周边，要么均匀分布于细胞质中。当线粒体聚集在毛细血管周围时，以相同速率利用氧气的细胞所需的毛细血管氧分压要低得多。考虑了两种将能量从周边线粒体分配到细胞其他部分的替代机制；即ATP或磷酸肌酸的扩散，并伴有足够的肌酸激酶以确保大约P载体之间的平衡。后者具有明显优势，似乎足以向相当大的无线粒体细胞核心（例如直径24微米）供应能量，在最大工作速率下，ADP水平或ATP水解自由能的变化非常小。因此，提出了一种可行的传统克罗格模型替代方案，该方案考虑了线粒体聚集导致的扩散途径不均匀性。
