Warren S A, Warren K G, Greenhill S, Paterson M
Can Med Assoc J. 1982 Feb 15;126(4):377-82, 385.
At the University of Alberta's multiple sclerosis research clinic 100 patients with multiple sclerosis were matched to control patients for age, sex, race and zone of residence before the age of 15 years. Case and control subjects were interviewed and information was collected by questionnaire on factors that might play a role in the development of multiple sclerosis. The only factors found to be significantly associated with the development of this disorder were a history of leisure time spent in physical activities before the onset of symptoms, exposure to animal illness -- specifically canine distemper -- and a history of severe or prolonged emotional stress. The study also confirmed a familial predisposition to multiple sclerosis and suggested a relation between the disorder and a personal or family history of diabetes mellitus.
在阿尔伯塔大学的多发性硬化症研究诊所,100名多发性硬化症患者在年龄、性别、种族和15岁前的居住区域方面与对照患者进行了匹配。对病例组和对照组受试者进行了访谈,并通过问卷调查收集了可能在多发性硬化症发病中起作用的因素的信息。发现与这种疾病的发生显著相关的唯一因素是症状出现前休闲时间进行体育活动的历史、接触动物疾病——特别是犬瘟热——以及严重或长期情绪压力的历史。该研究还证实了多发性硬化症的家族易感性,并表明该疾病与个人或家族糖尿病史之间存在关联。