Davis J W, Davis R F, Hassanein K M
Can Med Assoc J. 1982 Mar 15;126(6):637-9.
After abstinence for at least 8 hours, 20 healthy habitual smokers smoked two unfiltered cigarettes during each of two 20-minute periods separated by 48 hours. They had taken one 0.32-g tablet of acetylsalicylic acid (ASA) the night before the second period. The mean platelet aggregate ratios in venous blood taken immediately before and after each period of smoking were 0.79 and 0.70 respectively when ASA had not been taken beforehand and 0.89 and 0.91 when it had. The mean after smoking was significantly higher when ASA had been taken beforehand. In conjunction with the previous finding that in nonsmokers ASA prevented a lowering of the platelet aggregate ratio by experimental smoking without affecting the ratio before smoking, the data from the present study suggest that ASA abolishes both acute and longer-lasting effects of tobacco smoke on the platelet aggregate ratio in healthy habitual smokers.
在至少禁欲8小时后，20名健康的习惯性吸烟者在两个间隔48小时的20分钟时间段内，各吸两支未过滤香烟。在第二个时间段前一晚，他们服用了一片0.32克的乙酰水杨酸（ASA）。在未预先服用ASA时，每个吸烟时间段前后立即采集的静脉血中血小板聚集率平均值分别为0.79和0.70；在预先服用ASA时，该平均值分别为0.89和0.91。预先服用ASA后，吸烟后的平均值显著更高。结合之前的研究发现，即对于不吸烟者，ASA可防止实验性吸烟导致血小板聚集率降低，同时不影响吸烟前的比率，本研究数据表明，ASA消除了烟草烟雾对健康习惯性吸烟者血小板聚集率的急性和长期影响。
