Krasovich M, Benson B
Cell Tissue Res. 1982;223(1):155-63. doi: 10.1007/BF00221506.
Previous studies in rabbits and mice have revealed distinct circadian rhythms in the number of pinealocyte granulated vesicles (PGVs) and control of their synthesis and/or secretion by sympathetic nerves. The present study demonstrates the absence of a circadian rhythm in PGV content in hamsters "functionally pinealectomized" by maintenance under long photoperiod (L/D = 14/10 h). On the other hand, a highly significant rhythm of low amplitude was noted in PGVs of hamsters placed in photoperiods (less than 12.5 h) which are known to initiate pineal antigonadotropic activity. Bilateral optic enucleation, which also leads to pineal-mediated gonadal atrophy in the hamster, produced a significant decrease in the number of perivascular PGVs when compared to intact control animals. Daily late afternoon injections of melatonin produced no significant difference in the number of PGVs between treated and control animals at any sample time examined.
先前对兔子和小鼠的研究表明，松果体细胞颗粒小泡（PGV）的数量存在明显的昼夜节律，且交感神经对其合成和/或分泌具有调控作用。本研究表明，长期处于长光照周期（光照/黑暗 = 14/10小时）“功能性松果体切除”的仓鼠，其PGV含量不存在昼夜节律。另一方面，处于已知能引发松果体抗促性腺活性的光照周期（小于12.5小时）的仓鼠，其PGV呈现出低幅度的高度显著节律。双侧眼球摘除也会导致仓鼠松果体介导的性腺萎缩，与完整对照动物相比，血管周围PGV的数量显著减少。在任何检查的采样时间，每天傍晚注射褪黑素，处理组和对照组动物的PGV数量均无显著差异。
