Ray J, Lerner R A
Cell. 1982 Jan;28(1):91-8. doi: 10.1016/0092-8674(82)90378-6.
Recent biochemical and genetic evidence has shown that carbohydrate-binding protein (CBP-26) is intimately involved in the cell-cell cohesion process. We have isolated a cell-surface-associated receptor molecule for CBP-26 by affinity chromatography. The receptor has a molecular weight of 80,000 daltons. The CBP receptor is constitutively expressed during development. Most significantly, the receptor, when added to aggregation-competent cells, blocks the cells' ability to reaggregate. These results suggest that CBP and its receptor play an important role in the cell cohesion and aggregation process.
最近的生化和遗传学证据表明，碳水化合物结合蛋白（CBP - 26）密切参与细胞间黏附过程。我们通过亲和层析分离出了一种CBP - 26的细胞表面相关受体分子。该受体的分子量为80,000道尔顿。CBP受体在发育过程中持续表达。最显著的是，当将该受体添加到具有聚集能力的细胞中时，会阻断细胞重新聚集的能力。这些结果表明，CBP及其受体在细胞黏附和聚集过程中起重要作用。
