Charhon S A, Edouard C M, Arlot M E, Meunier P J
Clin Orthop Relat Res. 1982 Jan-Feb(162):255-63.
In order to determine the effects of parathyroid hormone on bone formation, mean wall thickness (MWT) of trabecular bone packets was measured on transilial undecalcified bone biopsies from 26 patients (14 females and 12 males) with primary hyperparathyroidism (HPT). Mean value of MWT in HPT patients (45.2 +/- 5.8 microns) was found to be significantly lower than in 35 controls (50.1 +/- 8.5 microns) (p less than 0.001). This difference is due to a significant reduction of MWT in HPT females before 50 years of age (46.0 +/- 2.3 microns) when compared with controls (56.2 +/- 7.1 microns; p less than 0.05), whereas there is no significant difference of average MWT in males of any age or in females after 50. These reductions of MWT could explain the rarefaction of spongy bone previously noticed in HPT females younger than 50 years. Furthermore, because of the mild depression of the osteoblastic activity measured by tetracycline double-labeling in HPT, the osteoblastic formation period was determined to be shortened in females before 50 years, and lengthened in females after 50 years of age and in males of any age. This could explain the anabolic effects of 1-34 hPTH fragment on trabecular bone volume in postmenopausal osteoporosis.
为了确定甲状旁腺激素对骨形成的影响，对26例原发性甲状旁腺功能亢进症（HPT）患者（14名女性和12名男性）的经髂骨未脱钙骨活检标本测量了小梁骨包块的平均壁厚度（MWT）。发现HPT患者的MWT平均值（45.2±5.8微米）显著低于35名对照组患者（50.1±8.5微米）（p<0.001）。这种差异是由于50岁之前的HPT女性的MWT显著降低（46.0±2.3微米），与对照组（56.2±7.1微米；p<0.05）相比，而任何年龄的男性或50岁之后的女性的平均MWT没有显著差异。MWT的这些降低可以解释之前在50岁以下的HPT女性中观察到的海绵骨稀疏现象。此外，由于通过四环素双标记测量的HPT患者成骨细胞活性轻度降低，确定50岁之前的女性成骨细胞形成期缩短，50岁之后的女性和任何年龄的男性成骨细胞形成期延长。这可以解释1-34 hPTH片段对绝经后骨质疏松症患者小梁骨体积的合成代谢作用。
