伴有结外受累的结节硬化型霍奇金淋巴瘤的治疗反应。

The response to treatment of nodular sclerosing Hodgkin's disease with extranodal involvement.

作者信息

Hudson G V, Jelliffe A M, Vaughan Hudson G, Maclennan K A

出版信息

Clin Radiol. 1982 Mar;33(2):141-4. doi: 10.1016/s0009-9260(82)80038-x.

Abstract

A study of the relationship between extranodal involvement and subsequent relapse has been undertaken in 32 patients with Stage IV nodular sclerosing Hodgkin's disease treated by chemotherapy. All patients were investigated and treated according to protocols of the British National Lymphoma Investigation. The most significant observation is that patients classified Stage IV by virtue of contiguous extranodal extension from bulky nodal lesions are inadequately treated by chemotherapy alone. Overall, 11 out of 12 (E) stage patients had residual or recurrent disease following quadruple chemotherapy. Four of these patients have since been rendered disease-free by radiotherapy.

摘要

对32例接受化疗的IV期结节硬化型霍奇金病患者进行了一项关于结外受累与后续复发关系的研究。所有患者均按照英国国家淋巴瘤研究方案进行调查和治疗。最显著的观察结果是，仅通过化疗对因肿大淋巴结病灶连续性结外扩展而被分类为IV期的患者治疗不足。总体而言，12例（E）期患者中有11例在四联化疗后出现残留或复发性疾病。其中4例患者后来通过放疗实现了无病状态。