Craig C P
Compr Ther. 1982 Feb;8(2):13-8.
Gram-negative septicemia is an old disease with dramatic changes in the arena of modern medicine. Whereas it was most often the domain of the infectious disease specialist and the abdominal surgeon 25 years ago, it is now managed in most medical practice specialties. It requires thorough understanding by all practitioners. Its physiology is increasingly well understood. The relationships between sepsis and host underlying diseases are important. Nonspecific therapies are important for early management of septicemia and impending shock, but specific application of immunotherapy in the form of antibody or vaccines, antibiotics selected for the most likely organism, and perhaps even pharmacotherapy directed at recognized intrinsic mediators of host responses to bacteremia, hold the greatest promise for a successful outcome.
革兰氏阴性菌败血症是一种古老的疾病，在现代医学领域发生了巨大变化。25年前，它大多是传染病专家和腹部外科医生的诊疗范畴，而现在大多数医学专科都参与其治疗。所有从业者都需要深入了解它。其生理学机制越来越为人所熟知。败血症与宿主基础疾病之间的关系很重要。非特异性疗法对于败血症早期治疗和即将发生的休克至关重要，但以抗体或疫苗形式进行的免疫疗法、针对最可能的病原体选择的抗生素，甚至针对宿主对菌血症反应中公认的内源性介质的药物治疗，有望带来最成功的治疗结果。
