Kühr J
Chirurg. 1982 Mar;53(3):160-4.
The influence of immobilisation on the number and function of osteoblasts was determined by morphological examination of normal rabbit bone and that that had been inactivated through surgery. Contrary to earlier supposition, after inactivation not only the osteoclasts but also the osteoblasts increase distinctly. Even retardation of the parathyroid gland by magnesium does not lead to decrease of the osseous structure. Therefore, it can be concluded that disuse osteoporosis is normally produced in its first weeks by a considerable activity decrease of even more osteoblasts and less by increased function of osteoclasts. The increase in number of osteoblasts and their decreased activity after immobilisation indicate that the mechanical stimulus gives the essential impulse for full osteoblast function.
通过对正常兔骨以及经手术使其失活的兔骨进行形态学检查，确定了固定对成骨细胞数量和功能的影响。与早期的推测相反，失活后不仅破骨细胞明显增加，成骨细胞也明显增加。即使通过镁抑制甲状旁腺也不会导致骨结构减少。因此，可以得出结论，废用性骨质疏松在最初几周通常是由更多成骨细胞的显著活性降低引起的，而不是由破骨细胞功能增强引起的。固定后成骨细胞数量增加但活性降低，这表明机械刺激为成骨细胞的充分功能提供了关键的刺激。
