Ohman U
Dis Colon Rectum. 1982 Apr;25(3):209-14. doi: 10.1007/BF02553102.
The mean incidence of colorectal carcinoma in persons under age 40 in Sweden is 1.74/100,000/year. Over a 30-year period, 1950 through 1979, 1061 patients with colorectal carcinoma were seen, 48 of whom where under age 40 (21 to 39 years) and in this study were compared with older patients. Carcinoma was superimposed upon ulcerative colitis in 18 patients. All patients treated for palliation died within two years. Curability rate. 67 per cent, and the proportion of Dukes' A lesions were the same as in older patients, whereas young patients had fewer B and more C lesions. Five-year survival was 33 per cent overall and 50 per cent in curable cases, not different from the rates in older patients (33 and 47 per cent). Five-year survival was 100 per cent in stage A, 50 per cent in stage B, and 33 per cent in stage C. The age factor had no impact upon survival, and colitic origin of a carcinoma did not decrease survival more than did carcinoma itself. It is concluded that colorectal carcinoma in patients under age 40 differs in no respect from the disease in older patients.
瑞典40岁以下人群中结直肠癌的平均发病率为每年1.74/100,000。在1950年至1979年的30年期间，共诊治了1061例结直肠癌患者，其中48例年龄在40岁以下（21至39岁），本研究将这些患者与老年患者进行了比较。18例患者的癌肿发生于溃疡性结肠炎之上。所有接受姑息治疗的患者均在两年内死亡。治愈率为67%，Dukes' A期病变的比例与老年患者相同，而年轻患者的B期病变较少，C期病变较多。总体五年生存率为33%，可治愈病例的五年生存率为50%，与老年患者的生存率（33%和47%）无差异。A期五年生存率为100%，B期为50%，C期为33%。年龄因素对生存率无影响，癌肿起源于结肠炎并不比癌肿本身更降低生存率。结论是，40岁以下患者的结直肠癌与老年患者的该病在各方面均无差异。
