Koppert H C, van Rij G
Doc Ophthalmol. 1982 Jan 29;52(3-4):339-45. doi: 10.1007/BF01675864.
In February 1980 acute keratoconjunctivitis was seen in a girls' class in a school in Rotterdam. Bacteriological and virological examination was performed on 20 girls. The agent causing this epidemic could not be demonstrated. Three patients had phlyctens at the limbus. In the year following this observation (March 1980 till March 1981) 42 cases of phlyctenular keratoconjunctivitis were examined prospectively. The condition was most commonly seen in 13- to 18-year old girls. The phlycten can be considered as an elementary form of inflammation in the conjunctiva and cornea, based on an immune reaction of the delayed type (Gell and Coombs' type IV). The hypersensitivity to tuberculin, which was formerly an important feature of this inflammation ('scrofulous ophthalmia'), is of little importance in the Netherlands at the present day. However, in every case of phlyctenular keratoconjunctivitis tuberculosis should still be excluded by the medical history, and if necessary by a Mantoux reaction.
1980年2月，鹿特丹一所学校的一个女生班级出现了急性角结膜炎。对20名女生进行了细菌学和病毒学检查。此次疫情的病原体未能查明。有3名患者在角膜缘出现了泡性病变。在此次观察之后的一年（1980年3月至1981年3月），对42例泡性角结膜炎患者进行了前瞻性检查。这种疾病最常见于13至18岁的女孩。基于迟发型免疫反应（盖尔和库姆斯IV型），泡性病变可被视为结膜和角膜炎症的一种基本形式。过去，对结核菌素过敏是这种炎症（“瘰疬性眼炎”）的一个重要特征，但目前在荷兰已不太重要。然而，在每一例泡性角结膜炎病例中，仍应通过病史排除结核病，必要时进行结核菌素试验。
