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家兔中三甲氧苯乙胺的药代动力学参数。

Pharmacokinetic parameters of mescaline in rabbits.

作者信息

Van Peteghem C, Heyndrickx A, Van Zele W

出版信息

Eur J Drug Metab Pharmacokinet. 1982 Jan-Mar;7(1):1-3. doi: 10.1007/BF03189535.

DOI:10.1007/BF03189535
PMID:7067718
Abstract

By means of a highly specific and sensitive mass fragmentographic method mescaline was measured in rabbit plasma samples, taken at various points after an i.v. injection. The pharmacokinetic behaviour conformed to the two-compartment open model. Half-life times of alpha and beta phases, velocity constants and steady-state distribution volumes of four subjects are reported.

摘要

通过一种高度特异性和灵敏的质量碎片图谱法,对静脉注射后不同时间点采集的家兔血浆样本中的三甲氧苯乙胺进行了测定。药代动力学行为符合二室开放模型。报告了四名受试者的α相和β相半衰期、速度常数以及稳态分布容积。

相似文献

1
Pharmacokinetic parameters of mescaline in rabbits.家兔中三甲氧苯乙胺的药代动力学参数。
Eur J Drug Metab Pharmacokinet. 1982 Jan-Mar;7(1):1-3. doi: 10.1007/BF03189535.
2
GLC-mass spectral determination of mescaline in plasma of rabbits after intravenous injection.
J Pharm Sci. 1980 Jan;69(1):118-20. doi: 10.1002/jps.2600690139.
3
Disposition of 14C-mescaline by rabbit lung.家兔肺对14C-三甲氧苯乙胺的处置
J Pharmacol Exp Ther. 1977 Feb;200(2):394-401.
4
Effects of aminoacetonitrile, an amine oxidase inhibitor, on mescaline metabolism in the rabbit.胺氧化酶抑制剂氨基乙腈对家兔中仙人掌碱代谢的影响。
Biochem Pharmacol. 1975 Jan 1;24(1):119-25. doi: 10.1016/0006-2952(75)90323-8.
5
Placental transfer and fetal distribution of mescaline- 14 C in monkeys.14C-麦司卡林在猴子体内的胎盘转运及胎儿分布
J Pharmacol Exp Ther. 1972 Nov;183(2):427-32.
6
Effect of ventilation on removal of [14C]mescaline by perfused rabbit lung.通气对灌注兔肺清除[14C]麦司卡林的影响。
Biochem Pharmacol. 1977 Aug 1;26(15):1446-8. doi: 10.1016/0006-2952(77)90373-2.
7
Placental transfer and tissue distribution of mescaline- 14 C in the mouse.
J Pharmacol Exp Ther. 1973 Feb;184(2):489-93.
8
Oxidative metabolism of mescaline in the central nervous system. IV. In vivo metabolism of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine.
Biochem Pharmacol. 1974 Jan 15;23(2):273-87. doi: 10.1016/0006-2952(74)90418-3.
9
Prediction of mescaline clearance by rabbit lung and liver from enzyme kinetic data.根据酶动力学数据预测兔肺和肝脏对三甲氧苯乙胺的清除率。
Biochem Pharmacol. 1980 Feb;29(2):253-5. doi: 10.1016/0006-2952(80)90337-8.
10
Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry.采用气相色谱/质谱法对人血浆中苯乙胺类新型毒品和三甲氧苯乙胺进行筛查及定量验证。
J Mass Spectrom. 2005 Jun;40(6):785-95. doi: 10.1002/jms.853.

本文引用的文献

1
GLC-mass spectral determination of mescaline in plasma of rabbits after intravenous injection.
J Pharm Sci. 1980 Jan;69(1):118-20. doi: 10.1002/jps.2600690139.
2
Metabolic fate of mescaline in man.仙人球毒碱在人体内的代谢命运。
Psychopharmacologia. 1966;9(1):48-63. doi: 10.1007/BF00427703.
3
Peyote constituents: chemistry, biogenesis, and biological effects.佩奥特仙人掌的成分:化学、生物合成及生物学效应。
J Pharm Sci. 1970 Dec;59(12):1699-727. doi: 10.1002/jps.2600591202.
4
Radioimmunoassays of 3,4,5-trimethoxyphenethylamine (mescaline) and 2,5-dimethoxy-4-methylphenyl-isopropylamine(DOM).
Anal Biochem. 1974 Aug;60(2):551-9. doi: 10.1016/0003-2697(74)90266-8.