盐酸维洛沙嗪在人体中的药代动力学。

Pharmacokinetics of viloxazine hydrochloride in man.

作者信息

Vandel B, Vandel S, Jounet J M, Blum D

出版信息

Eur J Drug Metab Pharmacokinet. 1982 Jan-Mar;7(1):65-8. doi: 10.1007/BF03189545.

Abstract

The pharmacokinetic characteristics of a new antidepressant, viloxazine hydrochloride, were investigated in five males and five females to study sex differences. Plasma levels were determined over a period of 9 h after a single dose of viloxazine of 100 mg (expressed as base). The half life of the drug was in the range of 2.19 - 4.21 for females and 2.61 - 4.31 h for males. The maximum plasma levels occurred in 29 - 171 min of the oral dose for females and 54 - 155 min for males. They reached 1382 - 1769 ng/ml-l for females and 1108 - 2932 ng/ml for males. Pharmacokinetic data were not statistically different between males and females.

摘要

为研究性别差异，对5名男性和5名女性进行了新型抗抑郁药盐酸维洛沙嗪的药代动力学特征研究。单次服用100毫克（以碱计）维洛沙嗪后9小时内测定血浆水平。该药物的半衰期女性为2.19 - 4.21小时，男性为2.61 - 4.31小时。女性口服给药后29 - 171分钟达到最大血浆水平，男性为54 - 155分钟。女性血浆水平达到1382 - 1769纳克/毫升，男性为1108 - 2932纳克/毫升。男性和女性的药代动力学数据无统计学差异。