Intramitochondrial location of the molecular forms of chicken liver mitochondrial malate dehydrogenase.

1. The two molecular forms of mitochondrial malate dehydrogenase are partly bound to the mitochondrial membranes. 2. The A form is located on the outer surface of the inner mitochondrial membrane and also in the intermembrane space. 3. The B form of the enzyme appears in the matrix and bound in part, probably, to the inner surface of the inner mitochondrial membrane. 4. Glutamate dehydrogenase, glutamate oxaloacetate transaminase, fumarase and lactate dehydrogenase are bound, to a greater or lesser extent, to the mitochondrial membranes, the fumarase having the highest degree of binding.