Winek C L, Pluskota M, Wahba W W
Forensic Sci Int. 1982 Mar-Apr;19(2):155-63. doi: 10.1016/0379-0738(82)90041-x.
Methods for the quantitation of flurazepam in plasma and bone marrow were developed for the purpose of determining the relationship between flurazepam concentrations in both tissues. Albino New Zealand rabbits, given flurazepam in doses of 5, 10, or 20 mg/kg, were sacrificed either one or three hours after drug administration. Flurazepam concentrations in plasma and bone marrow were determined utilizing a gas-liquid chromatograph equipped with an electron capture detector. the average plasma/bone marrow flurazepam ratios were 0.033 +/- 0.012 and 0.024 +/- 0.012 for rabbits sacrificed one hour and three hours after dosing, respectively. This study showed that a range of plasma flurazepam levels can be estimated from known bone marrow concentrations. The overall mean plasma/bone marrow ratio for all rabbits used in this study was 0.029 +/- 0.012 with a range of 0.010 to 0.055.
为了确定氟西泮在血浆和骨髓中的浓度关系，研究人员开发了血浆和骨髓中氟西泮的定量方法。给白化新西兰兔分别注射5、10或20mg/kg剂量的氟西泮，给药后1小时或3小时处死兔子。利用配备电子捕获检测器的气液色谱仪测定血浆和骨髓中的氟西泮浓度。给药后1小时和3小时处死的兔子，其血浆/骨髓氟西泮平均比值分别为0.033±0.012和0.024±0.012。该研究表明，可以根据已知的骨髓浓度估算一系列血浆氟西泮水平。本研究中所有兔子的血浆/骨髓总体平均比值为0.029±0.012，范围为0.010至0.055。
