精氨酸刺激胰高血糖素分泌时缺乏“大血浆胰高血糖素”反应。

Lack of a "big plasma glucagon" response during arginine stimulation of glucagon secretion.

作者信息

von Schenck H, Vasquez B, Unger R H

出版信息

Horm Metab Res. 1982 Feb;14(2):69-71. doi: 10.1055/s-2007-1018926.

DOI:10.1055/s-2007-1018926

Abstract

In order to determine whether the concentration of "big plasma glucagon" (BPG) levels changes in response to stimulation of the pancreatic A-cell, plasma samples were obtained from eight Type II diabetics before and during arginine infusion. The BPG and pancreatic glucagon (IRG3,500) components of glucagon were separated by gel filtration chromatography and fractions were assayed for immunoreactive glucagon (IRG) with 30K antisera. When chromatograms from basal and stimulated plasma were compared, no changes in BPG were observed, demonstrating that only IRG3,500 is involved in the increase in IRG observed in these patients.

摘要

为了确定“大血浆胰高血糖素”（BPG）水平的浓度是否会因胰腺A细胞受到刺激而发生变化，在精氨酸输注前及输注期间，从8名II型糖尿病患者身上采集了血浆样本。通过凝胶过滤色谱法分离胰高血糖素的BPG和胰腺胰高血糖素（IRG3,500）成分，并用30K抗血清对各组分进行免疫反应性胰高血糖素（IRG）检测。比较基础血浆和刺激后血浆的色谱图时，未观察到BPG有变化，这表明在这些患者中，只有IRG3,500参与了观察到的IRG增加。