Vik-Mo H, Moen P, Mjøs O D
Horm Metab Res. 1982 Feb;14(2):85-8. doi: 10.1055/s-2007-1018930.
The influence of an acute myocardial ischemia on lipoprotein lipase (LPL) activity in the myocardium was studied in open chest dogs. Myocardial ischemia was induced by occlusion of a branch of left descending coronary artery and biopsies were taken from non-ischemic and ischemic myocardium. After 60 min of myocardial ischemia a significantly lower LPL activity was found in full wall biopsies of ischemic than of non-ischemic left ventricular myocardium. The ischemia-induced reduction in LPL activity was most pronounced in the endocardial half of the myocardium. Reduction of LPL activity in the ischemic zone might contribute to limitation of the ischemic injury through reduction of FFA extraction from plasma triglycerides.
在开胸犬中研究了急性心肌缺血对心肌中脂蛋白脂肪酶（LPL）活性的影响。通过闭塞左冠状动脉降支的一个分支诱导心肌缺血，并从非缺血和缺血心肌中获取活检组织。心肌缺血60分钟后，发现缺血左心室心肌全层活检组织中的LPL活性明显低于非缺血组织。缺血诱导的LPL活性降低在心肌的心内膜一半最为明显。缺血区LPL活性的降低可能通过减少从血浆甘油三酯中提取游离脂肪酸来限制缺血损伤。
