Słomińska-Petelenz T, Petelenz T, Chruściel T L, Wilk J, Elertowicz M, Axenti I
Int J Clin Pharmacol Ther Toxicol. 1982 Mar;20(3):122-7.
In 24 patients with coronary ischemic disease the cardiovascular effects of 10-mg tablets of nifedipine given three times daily for 28 days was studied with noninvasive techniques before and after standard work load. Five patients did not complete the study because of drug nontolerance and lack of therapeutic effectiveness. In 19 patients nifedipine has been found to produce positive changes in left ventricle contraction parameters without influencing positively the ECG parameters. An increase in heart rate and the ratio of cardiac oxygen demand to general oxygen consumption was observed. The increase in systolic blood pressure after work load during nifedipine therapy contraindicates use of this drug in cardiac patients with arterial hypertension.
在24例冠心病患者中，采用无创技术在标准工作量前后研究了每日三次、每次10毫克硝苯地平片服用28天的心血管效应。5例患者因药物不耐受和缺乏治疗效果未完成研究。在19例患者中，已发现硝苯地平可使左心室收缩参数产生积极变化，但对心电图参数无积极影响。观察到心率增加以及心脏氧需求与总氧消耗之比增加。硝苯地平治疗期间工作量后收缩压升高表明该药物不适用于患有动脉高血压的心脏病患者。
