Dall'Aglio E, Zavaroni I, Alpi O, Coscelli C, Butturini U
Int J Clin Pharmacol Ther Toxicol. 1982 Mar;20(3):147-50.
Administration of pyridoxine-alpha-ketoglutarate (PAK) to a group of insulin-independent non-ketotic diabetics decreased (p less than 0.01) the plasma concentration of lactate response to isometric exercise. The mechanism of action of PAK could be interpreted as a consequence of changes induced by the drug on the Krebs' cycle with a subsequent reduction of lactate production.
