吗啡、脑啡肽及其合成类似物的镇痛活性评估。
Evaluation of the analgesic activity of morphine, enkephalins and their synthetic analogues.
作者信息
Aloisi F, Scotti de Carolis A, Longo V G
出版信息
Isr J Med Sci. 1982 Jan;18(1):183-6.
PMID:7068340
Abstract
In the rabbit, a morphine-like analgesic activity of natural and synthetic enkephalins has been demonstrated using the method of the return of corneal anesthesia due to conjunctival instillation of procaine. FK 33824 is the most effective drug in producing analgesia when administered intracerebroventricularly, whereas morphine is much more active when injected i.v. The effect of morphine and enkephalins is readily reversed by nalorphine (10 mg/kg, i.v.) indicating an involvement of opiate receptors in the CNS.
摘要
在家兔中，利用因结膜滴注普鲁卡因而使角膜麻醉恢复的方法，已证实天然和合成脑啡肽具有类吗啡镇痛活性。FK 33824经脑室内给药时是产生镇痛作用最有效的药物，而吗啡经静脉注射时活性更强。纳洛芬（10毫克/千克，静脉注射）可轻易逆转吗啡和脑啡肽的作用，这表明中枢神经系统中存在阿片受体参与其中。
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