Wainer E, Wittenberg C, Hochman B, Olah A J, Rosenfeld J B, Boner G
Isr J Med Sci. 1982 Feb;18(2):249-54.
Twenty patients with chronic renal failure being treated with hemodialysis were investigated in an attempt to ascertain whether hyperparathyroidism is an important etiologic factor in these patients' anemia. The patients were divided into two groups, one with hemoglobin of greater than 8 g/dl and the other with hemoglobin of less than 8 g/dl. These groups differed in blood transfusion requirements and in serum iron saturation. There was no difference between their levels of serum calcium, serum phosphate, serum alkaline phosphatase or serum parathyroid hormone. On bone biopsy endosteal fibrosis with bone marrow involvement was found in 2 of the 11 patients with high hemoglobin and in 5 of the 9 patients with low hemoglobin. Endosteal fibrosis with bone marrow involvement may thus be an important factor in the pathogenesis of anemia, and its presence or absence in association with hyperparathyroidism may explain the controversial observations reported by other investigators.
对20名正在接受血液透析治疗的慢性肾衰竭患者进行了调查，以确定甲状旁腺功能亢进是否是这些患者贫血的重要病因。患者被分为两组，一组血红蛋白大于8 g/dl，另一组血红蛋白小于8 g/dl。这两组在输血需求和血清铁饱和度方面存在差异。他们的血清钙、血清磷、血清碱性磷酸酶或血清甲状旁腺激素水平没有差异。在骨髓活检中，11名血红蛋白高的患者中有2名、9名血红蛋白低的患者中有5名发现有骨髓受累的骨内膜纤维化。因此，骨髓受累的骨内膜纤维化可能是贫血发病机制中的一个重要因素，其与甲状旁腺功能亢进的关联与否可能解释了其他研究者报告的相互矛盾的观察结果。
