Rachelefsky G S, Katz R M, Siegel S C
J Allergy Clin Immunol. 1982 Apr;69(4):382-7. doi: 10.1016/0091-6749(82)90150-6.
We evaluated the role of antimicrobials in the treatment of chronic maxillary sinusitis in children with respiratory allergy. Night and day cough, nasal obstruction, rhinorrhea, postnasal seen. Eighty-four children were treated in a double-blind manner with either amoxicillin, erythromycin, trimethoprim-sulfamethoxazole, or an antihistamine decongestant (carbinoxamine maleate-pseudoephedrine HCl). Radiographic and clinical responses were best with amoxicillin, but trimethoprim-sulfamethoxazole was an adequate alternative. This study demonstrates that allergic children with chronic sinusitis with associated chronic respiratory symptoms are likely to respond clinically and radiologically with antimicrobial treatment.
我们评估了抗菌药物在治疗患有呼吸道过敏的儿童慢性上颌窦炎中的作用。记录了日夜咳嗽、鼻塞、流涕、鼻后滴漏症状。84名儿童以双盲方式接受阿莫西林、红霉素、甲氧苄啶-磺胺甲恶唑或抗组胺减充血剂（马来酸氯苯那敏-盐酸伪麻黄碱）治疗。阿莫西林治疗后的影像学和临床反应最佳，但甲氧苄啶-磺胺甲恶唑也是一种合适的替代药物。这项研究表明，患有慢性鼻窦炎并伴有慢性呼吸道症状的过敏儿童在接受抗菌治疗后可能在临床和影像学上出现反应。
