McArthur M C, Sohal R S
J Gerontol. 1982 May;37(3):268-74. doi: 10.1093/geronj/37.3.268.
The purpose of this investigation was to further elucidate the relationship between metabolic rate and life span by studying the effect of experimentally varied metabolic rate on in vitro lipid peroxidation, fluorescent age pigment accumulation, and aging in the adult milkweed bug. The metabolic rate was altered by housing the insects at 18 degrees, 25 degrees, and 30 degrees C. The life span of insects was inversely related to the ambient temperature. Metabolic rates, before the period of 10% mortality, were greater at the elevated temperatures, but in the last trimester of life the rates were higher at 25 degrees C than at 30 degrees C. The total average amount of oxygen consumption during the entire life span of the insects raised at different temperatures was statistically similar. Lipid peroxidation potential of the tissues and concentration of fluorescent age pigment increased with age at significantly faster rates in organisms raised at relatively higher temperatures. The results suggest a positive correlation between metabolic rate, aging, lipid peroxidation potential, and fluorescent age pigment concentration and are interpreted to support the concept that aging may be modulated by the rate of oxygen consumption.
本研究的目的是通过研究实验性改变的代谢率对成年乳草蝽体外脂质过氧化、荧光衰老色素积累和衰老的影响，进一步阐明代谢率与寿命之间的关系。通过将昆虫饲养在18摄氏度、25摄氏度和30摄氏度的环境中来改变代谢率。昆虫的寿命与环境温度呈负相关。在10%死亡率出现之前，较高温度下的代谢率更高，但在生命的最后三个月，25摄氏度时的代谢率高于30摄氏度时的代谢率。在不同温度下饲养的昆虫整个生命周期内的总平均耗氧量在统计学上相似。在相对较高温度下饲养的生物体中，组织的脂质过氧化潜力和荧光衰老色素浓度随年龄增长显著加快。结果表明代谢率、衰老、脂质过氧化潜力和荧光衰老色素浓度之间呈正相关，并被解释为支持衰老可能受耗氧率调节这一概念。
