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雪貂(Mustela putorius furo)实验性旋毛虫感染

Experimental Trichinella spiralis infection in the ferret, Mustela putorius furo.

作者信息

Campbell W C, Blair L S, Kung F Y, Ewanciw D V

出版信息

J Helminthol. 1982 Mar;56(1):55-8. doi: 10.1017/s0022149x0003501x.

DOI:10.1017/s0022149x0003501x
PMID:7069183
Abstract

Laboratory ferrets (Mustela putorius furo) were each inoculated with 500 larvae of a strain of Trichinella spiralis that had been passaged in mice for many generations. The recovery of adult worms from ferrets on Days 4 and 7 of infection represented a mean of 32% of the inoculum, with most of the worms being in the anterior three quarters of the small intestine. Larvae subsequently became encysted in the ferret musculature, with the diaphragm alone yielding as many as 5,750 larvae upon digestion. For comparative purposes, mice were each inoculated with 200 T. spiralis from the same batch of larvae. The recovery of adult worms from mice represented a mean of 54% of the inoculum. An abrupt decline in worm population, typical of infections in the mouse, was observed in both mouse and ferret hosts; in neither species had the decline begun on Day 7 of infection, but it had clearly begun by Day 11 and was essentially ended by Day 14.

摘要

在实验室中,每只雪貂(鼬属黑足鼬)接种了500条在小鼠体内传代了许多代的旋毛虫幼虫。在感染后的第4天和第7天,从雪貂体内回收的成虫平均占接种量的32%,大多数成虫位于小肠前三分之二处。随后,幼虫在雪貂肌肉组织中形成包囊,仅膈肌经消化后就可产生多达5750条幼虫。为作比较,每只小鼠接种了来自同一批幼虫的200条旋毛虫。从小鼠体内回收的成虫平均占接种量的54%。在小鼠和雪貂宿主中均观察到蠕虫数量的突然下降,这是小鼠感染的典型特征;在这两个物种中,感染第7天时均未开始下降,但在第11天时明显开始下降,并在第14天时基本结束。

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