Warner R A, Hill N E, Spear R, Mookherjee S, Smulyan H
J Electrocardiol. 1982 Apr;15(2):119-25. doi: 10.1016/s0022-0736(82)80004-6.
This study was carried out to evaluate the possible usefulness of the VCG obtained during right ventricular pacing in the diagnosis of right ventricular necrosis. Myocardial necrosis was produced by injecting 40% formalin into the ventricular walls of 18 open-chest mongrel dogs. The injections were made in the inferior wall of the left ventricle in nine dogs (Group A) and in the inferior wall of the right ventricle in the remaining nine dogs (Group B). Analysis of vectorcardiographic QRS loops obtained during artificial pacing of the right ventricular apex was made before and 60 minutes after the injections. In Group B, but not in Group A, the injections resulted in superior displacement of initial QRS forces as indicated by measurements of time, distance, amplitude and angle. The pacing VCG, performed in serial fashion, is a specific and sensitive means of detecting right ventricular inferior wall necrosis in the experimental animal. Application of these findings to the diagnosis of myocardial infarction in humans requires further investigation.
本研究旨在评估右心室起搏时获得的向量心电图（VCG）在诊断右心室坏死方面的可能用途。通过向18只开胸杂种犬的心室壁注射40%福尔马林来制造心肌坏死。9只犬（A组）的注射部位在左心室下壁，其余9只犬（B组）的注射部位在右心室下壁。在右心室心尖部人工起搏期间获得的向量心电图QRS环在注射前和注射后60分钟进行分析。在B组而非A组中，注射导致初始QRS力向上移位，这通过时间、距离、幅度和角度的测量得以体现。以连续方式进行的起搏VCG是检测实验动物右心室下壁坏死的一种特异且敏感的方法。将这些发现应用于人类心肌梗死的诊断需要进一步研究。
