取代2-氨基吡咯的99mTc标记亚氨基二乙酸衍生物作为大鼠肝胆显像剂的评价II。
Evaluation of 99mTc-labeled iminodiacetic acid derivatives of substituted 2-aminopyrroles as hepatobiliary imaging agents in rats II.
作者信息
Graham B W, Dejuliis C M, Mattson R J, Sowell J W
出版信息
J Pharm Sci. 1982 Mar;71(3):362-4. doi: 10.1002/jps.2600710328.
PMID:7069601
Abstract
The synthesis and biodistribution properties of 99mTc-labeled 5-substituted N-(3-cyano-4-methyl-2-pyrrylcarbamoylmethyl)iminodiacetic acids and a similar series of N1-methyl analogs are described. These compounds were compared with 99mTc-labeled N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid for hepatobiliary activity in the rat. The effects of structural modifications on biological activity are also reported.
摘要
描述了99mTc标记的5-取代N-(3-氰基-4-甲基-2-吡咯甲酰甲基)亚氨基二乙酸及其类似系列的N1-甲基类似物的合成和生物分布特性。将这些化合物与99mTc标记的N-(2,6-二甲基苯基甲酰甲基)亚氨基二乙酸在大鼠中的肝胆活性进行了比较。还报道了结构修饰对生物活性的影响。
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