琥珀酰胆碱后的呼吸暂停：一个家族四代人的遗传学研究
Apnoea following suxamethonium: the genetic study of four generations of a family.
作者信息
Morgan A A
出版信息
J Med Genet. 1982 Feb;19(1):22-5. doi: 10.1136/jmg.19.1.22.
Nineteen subjects were investigated as a result of apnoea following the administration of suxamethonium occurring in one member of the family. Examination of the blood for cholinesterase activity, dibucaine number, and fluoride number was carried out and the appropriate genotype determined. The significance of the genetic variation of plasma cholinesterase in relation to suxamethonium apnoea is discussed. Five subject had the genotype Eu1Eu1, seven were of genotype Eu1E1a, three were Eu1Es1, and four Ea1Es1. Nine members of the family were considered to be at risk for the administration of suxamethonium. The appropriate action to safeguard other members of the family following a case of apnoea is outlined. By routine preoperative blood examination, 92 of 100 cases of suxamethonium apnoea resulting from a genetic abnormality of plasma cholinesterase can be anticipated.
由于家族中的一名成员在使用琥珀胆碱后出现呼吸暂停，对19名受试者进行了调查。检测了血液中的胆碱酯酶活性、地布卡因值和氟化物值，并确定了相应的基因型。讨论了血浆胆碱酯酶基因变异与琥珀胆碱所致呼吸暂停的关系。5名受试者的基因型为Eu1Eu1，7名是Eu1E1a基因型，3名是Eu1Es1，4名是Ea1Es1。该家族中有9名成员被认为使用琥珀胆碱有风险。概述了在发生一例呼吸暂停后保护家族其他成员的适当措施。通过术前常规血液检查，可以预测100例因血浆胆碱酯酶基因异常导致的琥珀胆碱呼吸暂停中的92例。
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