Reversible dissociation of a bovine cardiac factor that supports survival of avian ciliary ganglionic neurones.

The relationship has been studied between a high and a low molecular weight form of a bovine cardiac factor that supports the survival of avian ciliary ganglionic neurones in culture. Reversible dissociation of the high molecular weight form into identical or similarly sized subunits of apparent molecular weight in the range 15,000-30,000 has been demonstrated. In addition, other inactive high molecular weight components of cardiac extract were found to interact synergistically with both active forms of the factor.