D'Elia F L, Cooper H S, Mulholland S G
J Urol. 1982 Apr;127(4):665-7. doi: 10.1016/s0022-5347(17)53982-8.
Forty patients with stage O papillary transitional cell carcinoma of the bladder were tested for the presence or absence of ABH blood group substances. Of 25 tumors with antigens 21 (84 per cent) remained stage O, with a mean followup of 13.3 years. Of 15 tumors devoid of blood group substances 11 (73.3 per cent) progressed to stage B or greater in a mean of 4.3 years. Patients without antigens whose tumor remained stage O were followed for a mean of 10 years. Two patients with initially positive tumors subsequently showed loss of antigens and invasion. In 7 of 8 patients the benign epithelium showed a greater concentration of blood group substances than did the corresponding tumor. The presence or absence of blood group substances can be used to predict the biological behavior of stage O transitional cell carcinoma.
对40例膀胱O期乳头状移行细胞癌患者检测ABH血型物质的有无。在25例有抗原的肿瘤中，21例（84%）仍为O期，平均随访13.3年。在15例无血型物质的肿瘤中，11例（73.3%）在平均4.3年的时间里进展至B期或更高分期。肿瘤仍为O期的无抗原患者平均随访10年。2例最初呈阳性的肿瘤患者随后出现抗原丢失和浸润。8例患者中有7例的良性上皮比相应肿瘤显示出更高浓度的血型物质。血型物质的有无可用于预测O期移行细胞癌的生物学行为。
