Gasilin V S, Sidorenko B A, Kramer A A, Liakishev A A, Mazaev V P
Kardiologiia. 1982 Feb;22(2):14-22.
Selective coronarography and pharmacological test with intravenous administration of ergometrin have been carried out in 100 patients. The test permits one to demonstrate the vasospastic form of angina pectoris, which is encountered in patients with different degrees of lesions of the coronary arteries and different tolerance to exercise. Lack of coincidence in localization of ischaemic zones in the myocardium in tests with exercise and intravenous injection of ergometrin according to myocardium scintigraphy with 201Tl points to the possibility of existence of two forms of angina pectoris in the same patient, differing not only in the pathogenetic mechanisms but also in the localization of the ischaemic changes supervening in the myocardium. According to the data of echocardiography during the anginal attack with rise of the ST segment there is a more pronounced dilatation of the left ventricle cavity and decrease of the myocardial contractility than in the anginal attack with depression of the ST segment. In patients with spontaneous angina pectoris and rise of the ST segment corinfar exerted marked antianginal effect. Inderal was ineffective. In patients with angina pectoris and depression of the ST segment there was no difference between the two drugs.
对100例患者进行了选择性冠状动脉造影及静脉注射麦角新碱的药理试验。该试验能使人们发现心绞痛的血管痉挛形式，这种形式可见于冠状动脉病变程度不同及运动耐量不同的患者。根据用201Tl进行心肌闪烁扫描，运动试验和静脉注射麦角新碱试验中心肌缺血区定位不一致，这表明同一患者可能存在两种心绞痛形式，它们不仅发病机制不同，而且心肌缺血改变的部位也不同。根据超声心动图数据，在ST段抬高的心绞痛发作时，左心室腔扩张更明显，心肌收缩力下降，比ST段压低的心绞痛发作时更明显。在自发性心绞痛且ST段抬高的患者中，冠心宁有明显的抗心绞痛作用。心得安无效。在心绞痛且ST段压低的患者中，两种药物无差异。
