Kawa A, Ariyama T, Taniguchi Y, Kamisaki T, Kanehisa T
Acta Endocrinol (Copenh). 1978 Nov;89(3):432-7. doi: 10.1530/acta.0.0890432.
The possibility that intraventricular administration of 5,6-dihydroxytryptamine (5,6-DHT) can cause a development of denervation hypersensitivity to central 5-hydroxytryptamine (5-HT) was examined in rats with special reference to the pituitary-adrenocortical functions. Pretreatment with intraventricular injection of 5,6-DHT itself did not affect the basal concentrations or stress-induced increases of plasma B. The same pre-treatment, however, elicited augmented responses to subcutaneous injection of 5-HTP, i.e. there was a significant rise in the concentrations of plasma B as compared with those in the controls. These results suggest a development of denervation hypersensitivity to 5-HT following intraventricular injection of 5,6-DHT.
通过向大鼠脑室内注射5,6 - 二羟基色胺（5,6 - DHT）来探究其导致对中枢5 - 羟色胺（5 - HT）去神经超敏反应的可能性，并特别参考垂体 - 肾上腺皮质功能进行研究。脑室内注射5,6 - DHT本身进行预处理，并不影响血浆B的基础浓度或应激诱导的升高。然而，相同的预处理会引发对皮下注射5 - 羟色氨酸（5 - HTP）的增强反应，即与对照组相比，血浆B浓度显著升高。这些结果表明，脑室内注射5,6 - DHT后会出现对5 - HT的去神经超敏反应。
