Luchnik A N
Mol Biol (Mosk). 1982 Mar-Apr;16(2):258-70.
The fitness of two alternative chromosome models (unineme and bineme) to the vast body of biochemical, genetic, radiobiological and ultrastructural data is tested. Unineme model postulates the existence of only one DNA molecule (Watson--Crick double helix) per higher eukaryote chromosome at the G1 stage of the cell cycle. The bineme model postulates that eukaryotic G1-chromosome in higher eukaryotes consists of two homologous DNA molecules connected at the telomere and thus forming a circle. Comparative analysis shows that contemporary data favour the bineme model and disagree considerably with the unineme model.
测试了两种替代染色体模型(单线模型和双线模型)与大量生物化学、遗传学、放射生物学和超微结构数据的契合度。单线模型假定在细胞周期的G1期,每个高等真核生物染色体仅存在一个DNA分子(沃森-克里克双螺旋)。双线模型假定高等真核生物的真核G1染色体由两个在端粒处相连从而形成一个环的同源DNA分子组成。比较分析表明,当代数据支持双线模型,并且与单线模型有很大分歧。