Kitamura T, Tsuchihashi Y, Fujita S
Acta Neuropathol. 1978 Oct 13;44(1):31-9. doi: 10.1007/BF00691636.
Adult rabbits received stab wound in the cerebrum and were sacrificed at intervals of 20, 30, and 39 h thereafter. Each animal was injected intracerebrally with 3H-thymidine 2h before fixation. Altered brain tissues of the stratum radiatum of hippocampus were taken for examination. Response of "resting microglia" to stab wounding was investigated by electron microscopic autoradiography and by autoradiography applied on silver-impregnated materials. Following results were obtained: (1) Resting microglia undergo marked swelling shortly after the brain damage. We designate these cells as "swollen microglia". (2) Swollen microglia form the only cell population that proliferate actively in the initial stage of glial response to the brain injury, and (3) astroglia do not proliferate during the same experimental periods, in the rabbit hippocampus.
成年兔子大脑受到刺伤，然后分别在20小时、30小时和39小时后处死。每只动物在固定前2小时脑内注射3H-胸腺嘧啶核苷。取海马辐射层的病变脑组织进行检查。通过电子显微镜放射自显影术和应用于银浸染材料的放射自显影术研究“静止小胶质细胞”对刺伤的反应。获得了以下结果：（1）脑损伤后不久，静止小胶质细胞明显肿胀。我们将这些细胞称为“肿胀小胶质细胞”。（2）肿胀小胶质细胞是胶质细胞对脑损伤反应初期唯一活跃增殖的细胞群体，并且（3）在相同的实验期间，兔海马中的星形胶质细胞不增殖。
